Visible-UVC upconversion polymer films for prevention of microbial infection.
Hang ZhaoLiang ZhangJinsuo LuShouning ChaiJinliu WeiYuning YuRuoyan MiaoLvling ZhongPublished in: Journal of materials chemistry. B (2023)
Bacterial infections caused by the growth and reproduction of pathogenic bacteria on wounds are one of the main reasons that hinder wound healing. Antibacterial wound dressings protect wounds from bacterial infections. Herein, we developed a polymeric antibacterial composite film using polyvinyl alcohol (PVA) and sodium alginate (SA) as the substrate. The film used praseodymium-doped yttrium orthosilicate (Y 2 SiO 5 : Pr 3+ , YSO-Pr) to convert visible light into short-wavelength ultraviolet light (UVC) to kill bacteria. The YSO-Pr/PVA/SA showed upconversion luminescence in photoluminescence spectrometry tests, and the emitted UVC inhibited Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Escherichia coli and Pseudomonas aeruginosa ) bacteria in antibacterial tests. In vivo animal tests showed that YSO-Pr/PVA/SA is effective and safe for inhibiting bacteria in real wounds. The in vitro cytotoxicity test further confirmed the good biocompatibility of the antibacterial film. In addition, YSO-Pr/PVA/SA exhibited sufficient tensile strength. Overall, this study demonstrates the potential of upconversion materials for use in medical dressings.
Keyphrases
- wound healing
- gram negative
- energy transfer
- visible light
- quantum dots
- multidrug resistant
- room temperature
- photodynamic therapy
- pseudomonas aeruginosa
- staphylococcus aureus
- escherichia coli
- silver nanoparticles
- reduced graphene oxide
- cystic fibrosis
- anti inflammatory
- high resolution
- signaling pathway
- drug resistant
- mass spectrometry
- microbial community
- risk assessment
- acinetobacter baumannii
- ionic liquid
- klebsiella pneumoniae
- tandem mass spectrometry
- light emitting
- gas chromatography
- metal organic framework
- liquid chromatography