A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Raymond NoordamColleen M SitlaniChristy L AveryJames D StewartStephanie M GogartenKerri L WigginsStella TrompetHelen R WarrenFangui SunDaniel S EvansXiaohui LiJin LiAlbert V SmithJoshua C BisJennifer A BrodyEvan L BuschMark J CaulfieldYii-Der I ChenSteven R CummingsL Adrienne CupplesQing DuanOscar H FrancoRául Méndez-GiráldezTamara B HarrisSusan R HeckbertDiana van HeemstAlbert HofmanJames S FloydJan A KorsLenore J LaunerYun LiRuifang Li-GaoLeslie A LangeHenry J LinRenée de MutsertMelanie D NapierChristopher Newton-ChehNeil PoulterAlexander P ReinerKenneth M RiceJeffrey RoachCarlos J RodriguezFrits R RosendaalNaveed SattarPeter SeverAmanda A SeyerleP Eline SlagboomElsayed Z SolimanNona SotoodehniaDavid J StottTil StürmerKent D TaylorTimothy A ThorntonAndré G UitterlindenKirk C WilhelmsenJames G WilsonVilmundur GudnasonJ Wouter JukemaCathy C LaurieYongmei LiuDennis O Mook-KanamoriPatricia B MunroeJerome I RotterRamachandran S VasanBruce M PsatyBruno H StrickerEric A WhitselPublished in: Journal of medical genetics (2016)
Among Europeans, TCA interactions with variants in BRE and UBE2E2 were identified in relation to RR intervals. Among Hispanic/Latinos, variants in TGFBR3 modified the relation between TCAs and QT intervals. Future studies are required to confirm our results.