A First-in-Human Trial to Evaluate the Safety and Immunogenicity of a G Protein-Based Recombinant Respiratory Syncytial Virus Vaccine in Healthy Adults 18-45 Years of Age.
Xin ChengGan ZhaoAihua DongZhonghuai HeJiarong WangBrian JiangBo WangMiaomiao WangXuefen HuaiShijie ZhangShuangshuang FengHong QinBin WangPublished in: Vaccines (2023)
BARS13 had a generally good safety and tolerability profile, and no significant difference in terms of adverse reaction severity or frequency was observed between different dose groups. The immune response in repeat-dose recipients shows more potential in further study and has guiding significance for the dose selection of subsequent studies.