Lasibidoupins A and B, two new compounds from the stems of Lasianthus bidoupensis V.S. Dang & Naiki.
Nguyen Kim Tuyen PhamThi Diem Huong NguyenThi Mong Cam NguyenGia Dinh NguyenCong Doan HuynhThi Nga VoThi Quynh Trang NguyenThuc Huy DuongVan Son DangBui Linh Chi HuynhThi Ngoc Mai TranNguyen Kim Tuyen PhamPublished in: Natural product research (2021)
From the Lasianthus bidoupensis stems, two new compounds, including one new 9,10-anthraquinone, lasibidoupin A (1), and one new 6,7-benzocoumarin, lasibidoupin B (2), together with one known compound, 11-O-methyldamnacanthol (3) were isolated using chromatographic method. Their structures were determined by extensive HRMS, and NMR assignments. Compound 3 was reported for the first time from this species. New compounds (1 & 2) were tested for the cytotoxicity against three human cancer cell lines (MCF-7, HeLa, and NCI-H460) by SRB assay. As results, 1 & 2 exhibited significant cytotoxic activity against all cancer cell lines (IC50 ranged from 0.058 ± 0.003 to 0.177 ± 0.014 μM).