Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer.

Chao-Ran YuHiju HongJiaoyang LuXuan ZhaoWenjun HuSen ZhangYaping ZongZhihai MaoJianwen LiMingliang WangBo FengJing SunMinhua Zheng

Published in: Technology in cancer research & treatment (2019)

This in silico analysis provided a feasible and reliable strategy for systematic exploration of insightful target genes, pathways and mechanisms underlying the cetuximab insensitivity in colorectal cancer. B-cell lymphoma protein 2 was associated with favorable prognosis.

Keyphrases

genome wide
metastatic colorectal cancer
bioinformatics analysis
locally advanced
diffuse large b cell lymphoma
wild type
molecular docking
protein protein
squamous cell carcinoma
genome wide analysis
gene expression
amino acid
radiation therapy
rectal cancer