Lack of concentration-dependent local toxicity of highly concentrated (5%) versus conventional 0.5% bupivacaine following musculoskeletal surgery in a rat model.

Jasper G SteverinkFloris R van TolSuzanne BruinsAndre J SmorenburgMarianna A TryfonidouBas J OostermanMarijke R van DijkJos Malda Jorrit-Jan Verlaan

Published in: Journal of experimental orthopaedics (2023)

This pilot study found limited concentration-dependent local tissue effects of bupivacaine solutions concentrated up to 5.0% following musculoskeletal surgery in the rat study population.

Keyphrases

minimally invasive
coronary artery bypass
oxidative stress
pain management
surgical site infection
postoperative pain