Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non-demented adults.

Gilda E EnnisRebecca L KoscikYue MaErin M JonaitisCarol A Van HulleTobey J BetthauserAllison M RandallNathaniel ChinCorinne D EngelmanRozalyn AndersonIvonne SuridjanGwendlyn KollmorgenBradley T ChristianCynthia M CarlssonSanjay AsthanaSterling C JohnsonHenrik ZetterbergKaj BlennowBarbara B Bendlin

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2021)

In non-demented adults IR may not be directly associated with age-related change in AD biomarkers. Additional research is needed to determine mechanisms linking IR to cognitive decline.

Keyphrases

cognitive decline
mild cognitive impairment
insulin resistance
type diabetes
metabolic syndrome
polycystic ovary syndrome
cerebrospinal fluid
glycemic control