Phospholamban p.Arg14del cardiomyopathy is characterized by phospholamban aggregates, aggresomes, and autophagic degradation.
Wouter P Te RijdtJ Peter van TintelenAryan VinkAllard C van der WalRudolf A de BoerMaarten P van den BergAlbert J H SuurmeijerPublished in: Histopathology (2016)
PLN p.Arg14del cardiomyopathy is a biventricular cardiomyopathy characterized by large perinuclear PLN protein aggregates with a typical ultrastructural appearance of aggresomes. PLN detected by immunohistochemistry appears to be a sensitive and specific marker for this disease.
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