Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.
Nina GeidenstamYu-Han H HsuChristina M AstleyJosep M MercaderMartin RidderstråleMaria E GonzalezClicerio GonzalezJoel N HirschhornRany M SalemPublished in: PloS one (2019)
We have constructed and validated a generalizable MRS for future weight gain that is an independent predictor distinct from several other known risk factors. The MRS captures a composite biological picture of weight gain, perhaps hinting at the anabolic effects of preserved insulin sensitivity. Future investigation is required to assess the relationships between MRS-predicted weight gain and other obesity-related diseases.