Pamoic acid is an inhibitor of HMGB1·CXCL12 elicited chemotaxis and reduces inflammation in murine models of Pseudomonas aeruginosa pneumonia.

Federica De LeoAlice RossiFrancesco De MarchisCristina CiganaMedede MelessikeGiacomo QuiliciIda De FinoMalisa Vittoria MantonicoChantal FabrisAlessandra BragonziMarco Emilio BianchiGiovanna Musco

Published in: Molecular medicine (Cambridge, Mass.) (2022)

This work established the efficacy of treating inflammation in chronic respiratory diseases, including bacterial infections, by topical delivery in the lung of PAM, an inhibitor of HMGB1.

Keyphrases

pseudomonas aeruginosa
oxidative stress
biofilm formation
acinetobacter baumannii
staphylococcus aureus
wound healing
multidrug resistant
respiratory tract
drug induced
community acquired pneumonia