Relationship between body mass index and atopic dermatitis: a Mendelian randomization approach in exploring causality: a critical appraisal.
Catherina X PanY-H JeeK J MooreP KraftMaryam M AsgariPublished in: The British journal of dermatology (2021)
Atopic dermatitis (AD) is a common, chronic inflammatory skin disease with a complex etiology including genetic and environmental risk factors.1 Obesity has been associated with increased AD risk and severity,2 but a causal relationship has not been established. In the Journal of Allergy and Clinical Immunology, Budu-Aggrey et al.3 assessed the causality between elevated body mass index (BMI) and AD using a Mendelian randomization (MR)approach1 .
Keyphrases
- atopic dermatitis
- body mass index
- weight gain
- risk factors
- insulin resistance
- metabolic syndrome
- adverse drug
- type diabetes
- weight loss
- oxidative stress
- physical activity
- magnetic resonance
- genome wide
- emergency department
- gene expression
- copy number
- computed tomography
- adipose tissue
- risk assessment
- electronic health record