The Impact of Alcohol Use on Frontal White Matter in HIV.
Joseph M GullettDamon G LambEric PorgesAdam J WoodsJake RiekePaul ThompsonNeda JahanshadTalia M NirKaren TashimaRonald A CohenPublished in: Alcoholism, clinical and experimental research (2018)
This study provides evidence of HIV-related associations between alcohol use and indicators of axonal integrity loss along the ATR, a frontal pathway involved in the inhibition of addictive or unwanted behaviors. Reduced axonal integrity of this pathway was greatest in HIV+ participants with an AUD, even when considering the effect of age-adjusted disease length and severity (nadir CD4). This finding implicates a potential biological mechanism linking reduced integrity of frontal white matter to the high prevalence of AUD in an HIV+ population without dementia or hepatitis C.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- white matter
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- functional connectivity
- working memory
- south africa
- multiple sclerosis
- mild cognitive impairment
- oxidative stress
- risk assessment
- human health
- optical coherence tomography