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Proteomic and transcriptomic analyses of early and late-chronic Toxoplasma gondii infection shows novel and stage specific transcripts.

Andrew L GarfootGary M WilsonJoshua J CoonLaura J Knoll
Published in: BMC genomics (2019)
We have expanded the transcriptional profile of in vivo bradyzoites to 120 days post-infection and provided the first in vivo proteomic profile of T. gondii bradyzoites. The RNA sequencing depth of in vivo bradyzoite T. gondii was over 250-fold greater than previous reports and allowed us to identify low level transcripts and a novel bradyzoite-specific isoform of sporoAMA1.
Keyphrases
  • toxoplasma gondii
  • single cell
  • label free
  • rna seq
  • transcription factor
  • optical coherence tomography
  • emergency department
  • electronic health record
  • heat stress