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Neuroendocrine tumours of the breast: a genomic comparison with mucinous breast cancers and neuroendocrine tumours of other anatomic sites.

Fresia ParejaMahsa VahdatiniaCaterina MarchioSimon S K LeeArnaud Da Cruz PaulaFatemeh DerakhshanEdaise M Da SilvaPier SelenicaHiginio DopesoSarat ChandarlapatyHannah Y WenAnne Vincent-SalomonEdi BrogiBritta WeigeltJorge S Reis-Filho
Published in: Journal of clinical pathology (2020)
Breast NETs are heterogeneous and are characterised by an enrichment of mutations in transcription factors and likely constitute a spectrum of entities histologically and genomically related to MuBCs. While most breast NETs are distinct from ER-positive/HER2-negative IDC-NSTs, a subset of breast NETs appears to be genetically similar to common forms of ER-positive breast cancer, suggesting that some breast cancers may acquire neuroendocrine differentiation later in tumour evolution.
Keyphrases
  • positive breast cancer
  • transcription factor
  • breast cancer cells
  • genome wide