Digital Immune-Related Gene Expression Signatures In High-Grade Serous Ovarian Carcinoma: Developing Prediction Models For Platinum Response.

Fabian Dominik MairingerAgnes BankfalviKurt Werner Schmid Elena MairingerPawel MachRobert F H Walter Sabrina BorchertSabine Kasimir-BauerRainer KimmigPaul Buderath

Published in: Cancer management and research (2019)

Our results suggest that response to platinum-based therapy and DFS in ovarian HGSOC is associated with distinct gene-expression patterns related to the tumor immune-system. We generated predictive scoring systems which proved valid when applied to a set of 303 EOC patients.

Keyphrases

gene expression
high grade
end stage renal disease
dna methylation
low grade
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
genome wide
bone marrow
patient reported