Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation.

M L SchiavoneL CrisafulliC CamisaschiG De SimoneF R LiberatiE PalaganoN RucciF FicaraCristina Sobacchi

Published in: Stem cell research & therapy (2024)

We provide for the first time the characterization of SSPCs from mouse models of severe recessive osteopetrosis. We demonstrate that Rankl genetic deficiency in murine SSCs and functional blockade in hBMSCs reduce their osteogenic potential. Therefore, we propose that RANKL is an important regulatory factor of SSC features with translational relevance.

Keyphrases

bone loss
nuclear factor
genome wide
mouse model
mesenchymal stem cells
copy number
bone marrow
replacement therapy
intellectual disability
transcription factor
early onset
autism spectrum disorder
inflammatory response