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Role of blood derived cell fractions, temperature and sample transport on gene expression-based biological dosimetry.

Farah NasserLourdes Cruz-GarciaGrainne O'BrienChristophe Badie
Published in: International journal of radiation biology (2021)
In conclusion, temperature during the incubation period and cell fraction but not the storing conditions during transport can influence the transcriptional response of specific genes. However, FDXR and CCNG1 showed a consistent response under all the different conditions tested demonstrating their reliability as individual biological dosimetry biomarkers.
Keyphrases
  • gene expression
  • single cell
  • dna methylation
  • genome wide
  • stem cells
  • oxidative stress
  • mesenchymal stem cells
  • bone marrow