Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis.

Suguru YamamotoKeiko YamamotoYoshitoshi HiraoKeiichi YamaguchiKichitaro NakajimaMami SatoMiho KawachiMio DomonKei GotoKentaro OmoriNoriaki IinoHisaki ShimadaRyuzi AoyagiIsei EiShin GotoYuji GotoFumitake GejyoTadashi YamamotoIchiei Narita

Published in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2024)

HICBs adsorbed diverse proteins in ESKD patients with DRA, including those detected in amyloid lesions. Direct hemoperfusion utilizing HICBs may play a role in acting Aβ2M amyloidogenesis by reducing the amyloid-related proteins.

Keyphrases

mass spectrometry
liquid chromatography
ionic liquid
high resolution
high performance liquid chromatography
multiple myeloma
ms ms
tandem mass spectrometry
septic shock
simultaneous determination
smoking cessation