The protective effect of Astaxanthin on scopolamine - induced Alzheimer's model in mice.
Rania M MagadmiSara NassibiFatemah KamelAziza R Al-RafiahDuaa BakhshwinMaha JamalMohammed AlsieniAbdulhadi S BurzangiM A F ZaherMohammed BendaryPublished in: Neurosciences (Riyadh, Saudi Arabia) (2024)
The findings indicate that AST may offer therapeutic benefits against cognitive dysfunction in AD. This is attributed to its ability to reduce oxidative stress, control neuroinflammation, and enhance Akt-1 and pAkt levels, thereby underscoring its potential in AD treatment strategies.
Keyphrases
- diabetic rats
- oxidative stress
- high glucose
- signaling pathway
- traumatic brain injury
- cell proliferation
- cognitive decline
- high fat diet induced
- dna damage
- lps induced
- ischemia reperfusion injury
- cognitive impairment
- induced apoptosis
- endothelial cells
- inflammatory response
- cerebral ischemia
- adipose tissue
- mild cognitive impairment
- blood brain barrier
- subarachnoid hemorrhage