Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer.

Dhanir TailorCatherine C GoingAngel ResendezVineet KumarDhanya K NambiarYang LiArpit DheerajEdward Lewis LaGoryAli GhoochaniAlisha M BirkTanya StoyanovaJiangbin YeAmato J GiacciaQuynh-Thu LeRana P SinghGeorge W SledgeSharon J Pitteri Sanjay V Malhotra

Published in: British journal of cancer (2020)

SU212 directly activates AMPK in TNBC cells, but does not hamper glucose metabolism in normal cells. Our study provides compelling preclinical data for further development of SU212 for the treatment of TNBC.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
skeletal muscle
protein kinase
endoplasmic reticulum stress
signaling pathway
machine learning
electronic health record
big data
cell proliferation
artificial intelligence