Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition.

Claudia Demarta-GatsiCristina DoniniJames DuffyClaire SadlerJane StewartJane A BarberBelen Tornesi

Published in: Birth defects research (2022)

Deciphering if the EFD effects are dependent on PI4K inhibition, and/or via inhibition of other off-target kinases will require the generation of novel, more potent, and more specific PI4K inhibitors.

Keyphrases

oxidative stress
high glucose
drug induced
anti inflammatory
climate change