Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis.

Sébastien SangesLisa RiceLy TuEleanor ValenziJean-Luc CracowskiI David MontaniJulio C ManteroCamille TernynckGuillemette MarotAndreea M BujorEric HachullaDavid LaunayMarc HumbertChristophe GuignabertRobert Lafyatis

Published in: Annals of the rheumatic diseases (2022)

Chemerin seems an interesting surrogate biomarker for PVR in SSc-PAH. Increased chemerin serum levels and CMKLR1 expression by PA-SMCs may contribute to SSc-PAH pathogenesis by inducing PA-SMC proliferation.

Keyphrases

systemic sclerosis
pulmonary arterial hypertension
interstitial lung disease
pulmonary artery
pulmonary hypertension
polycyclic aromatic hydrocarbons
signaling pathway
coronary artery
idiopathic pulmonary fibrosis