Incidence, aetiology and neurodisability associated with severe microcephaly: a national surveillance study.
Rachel Louise KnowlesAmeenat Lola SoleboMariana Autran SampaioCharlotte Rebecca BrownJenefer SargentNgozi OluonyeJugnoo Sangeeta RahiPublished in: Archives of disease in childhood (2022)
Although severe microcephaly is uncommon, it is associated with high mortality, complex multimorbidity and neurodisability, thus representing a significant ongoing burden for families and healthcare services. Potentially preventable causes include preterm birth, hypoxic/ischaemic brain injury and congenital infections. Clinical guidelines are essential to standardise aetiological investigation and optimise multidisciplinary management.
Keyphrases
- brain injury
- preterm birth
- healthcare
- zika virus
- subarachnoid hemorrhage
- intellectual disability
- risk factors
- low birth weight
- early onset
- quality improvement
- gestational age
- cerebral ischemia
- public health
- cardiovascular events
- mental health
- clinical practice
- drug induced
- preterm infants
- type diabetes
- autism spectrum disorder
- coronary artery disease
- cardiovascular disease
- adverse drug
- health insurance