Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM).

Moshe LapidotAbigail E CaseEllen L WeisbergChengcheng MengSarah R WalkerSwati GargWei NiKlaus PodarYin Pun HungRuben D CarrascoAine KnottPrafulla C GokhaleSunil SharmaAlex PozhitkovPrakash KulkarniDavid A FrankRavi SalgiaJames D GriffinSrinivas V SaladiRaphael BuenoMartin Sattler

Published in: British journal of cancer (2021)

The results establish a novel and essential role for KDM4A in growth in preclinical models of MPM and identify potential therapeutic approaches to target KDM4A-dependent vulnerabilities.

Keyphrases

dna methylation
stem cells
cell therapy
gene expression
mesenchymal stem cells