Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction.

Vincent L BironAshlee MatkinMorris KostiukJordana WilliamsDavid W CoteJeffrey HarrisHadi SeikalyDaniel A O'Connell

Published in: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (2018)

DdPCR offers a novel and ultrasensitive method of detecting RAS and BRAF mutations from thyroid FNABs. BRAFV600E mutation testing by ddPCR may serve as a useful adjunct to increase sensitivity and specificity of thyroid FNAB.

Keyphrases

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gold nanoparticles
high throughput
mass spectrometry
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