Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia.

Diego Sánchez-MartínezNéstor TiradoSofia MensuradoAlba Martínez-MorenoPaola RomecínFrancisco Gutiérrez AgüeraDaniel V CorreiaBruno Silva-SantosPablo Menéndez

Published in: Journal for immunotherapy of cancer (2022)

Our results provide the proof-of-concept for a DOT-based next-generation allogeneic CAR-T therapy for AML.

Keyphrases

stem cell transplantation
bone marrow
induced apoptosis
hematopoietic stem cell
cell cycle arrest
acute myeloid leukemia
high dose
endoplasmic reticulum stress
cell death
oxidative stress
cell proliferation
acute lymphoblastic leukemia
nk cells
pi k akt