Cornelian Cherry Iridoid-Polyphenolic Extract Improves Mucosal Epithelial Barrier Integrity in Rat Experimental Colitis and Exerts Antimicrobial and Antiadhesive Activities In Vitro.
Marta Szandruk-BenderMaria RutkowskaAnna Merwid-LądBenita WiatrakAdam SzelągStanislaw DzimiraSobieszczańska BeataMałgorzata Krzystek-KorpackaAlicja Zofia KucharskaAgnieszka MatuszewskaBeata NowakNarcyz PióreckiAnna Duda-MadejUrszula WalczukMichał TurniakIwona Bednarz-MisaTomasz SozańskiPublished in: Oxidative medicine and cellular longevity (2020)
CE exerted a protective effect against experimental colitis via impaired mucosal epithelial barrier restoration and intestinal inflammatory response attenuation and given concomitantly with sulfasalazine counteracted colitis in a more effective way than sulfasalazine alone, which indicates their synergistic interaction. The beneficial effect of CE may also be due to its bacteriostatic and antiadhesive activities.