Cobalt-Catalyzed Enantioselective Alkenylation of Aldehydes.
Chuiyi LinJiwu ZhangZhao SunYinlong GuoQinglei ChongZhihan ZhangFanke MengPublished in: Angewandte Chemie (International ed. in English) (2024)
Catalytic enantioselective alkenylation of aldehydes with easily accessible alkenyl halides promoted by a chiral cobalt complex derived from a newly developed tridentate bisoxazolinephosphine is presented. Such processes represent an unprecedented reaction pathway for cobalt catalysis and a general approach that enable rapid construction of highly diversified enantioenriched allylic alcohols containing a 1,1-, 1,2-disubstituted and trisubstituted alkene as well as axial stereogenicity in up to 99 % yield and 99 : 1 er without the need of preformation of alkenyl-metal reagents. DFT calculations revealed the origin of enantioselectivity.
Keyphrases
- reduced graphene oxide
- density functional theory
- carbon nanotubes
- metal organic framework
- molecular dynamics
- single cell
- molecular dynamics simulations
- crystal structure
- room temperature
- ionic liquid
- breast cancer cells
- mass spectrometry
- capillary electrophoresis
- loop mediated isothermal amplification
- electron transfer