Derivation and external validation of a risk score for predicting HIV-associated tuberculosis to support case finding and preventive therapy scale-up: A cohort study.
Andrew F AuldAndrew D KerkhoffYasmeen HanifaRobin WoodSalome CharalambousYuliang LiuTefera AgizewAnikie MathomaRosanna BoydAnand DateRay W ShiraishiGeorge BicegoUnami Mathebula-ModongoHeather AlexanderChristopher SerumolaGoabaone Rankgoane-PonoPontsho PonoAlyssa M FinlayJames C ShepherdTedd V EllerbrockAlison D GrantKatherine L FieldingPublished in: PLoS medicine (2021)
The simple and feasible clinical score allowed for prioritization of sensitivity and NPV, which could facilitate reductions in mortality from undiagnosed TB and safer administration of TPT during proposed global scale-up efforts. Differentiation of risk by clinical score cutoff allows flexibility in designing differentiated HIV-TB care to maximize impact of available resources.
Keyphrases
- mycobacterium tuberculosis
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv aids
- human immunodeficiency virus
- hiv testing
- hepatitis c virus
- healthcare
- quality improvement
- men who have sex with men
- risk factors
- stem cells
- emergency department
- cardiovascular disease
- pulmonary tuberculosis
- affordable care act
- cell therapy