Tau positron emission tomography imaging in C9orf72 repeat expansion carriers.

Cindy V LyL KoenigJ ChristensenB GordonH BeaumontJeffrey R MillmanJ ChenY SuB NelsonJ Jockel-BalsarottiC DrainG JeromeJ C MorrisA M FaganM B HarmsT L S BenzingerT M MillerBeau M Ances

Published in: European journal of neurology (2019)

C9orf72 expansion carriers exhibited increased AV-1451 uptake in entorhinal cortex compared to cognitively normal controls, suggesting a propensity for primary age-related tauopathy. However, AV-1451 accumulation was not associated with psychometric performance in our cohort.

Keyphrases

positron emission tomography
computed tomography
high resolution
pet ct
pet imaging
cognitive decline
functional connectivity
cerebrospinal fluid
mild cognitive impairment