Reports of Lactic Acidosis Attributed to Metformin, 2015-2018.
James H FlorySean HennessyClifford J BaileyCatherine M ViscoliPublished in: Diabetes care (2019)
The increased reports deserve attention, but the PRR's stability and FAERS's known limitations, including lack of a denominator or control group, do not permit the conclusion that U.S. MALA rates have increased. Further study with more robust data sources is needed.