Can IM-MS Collision Cross Sections of Biomolecules Be Rationalized Using Collision Cross-Section Trends of Polydisperse Synthetic Homopolymers?
Jean R N HalerPhilippe MassonnetJohann FarGregory UpertNicolas GillesGilles MourierLoïc QuintonEdwin De PauwPublished in: Journal of the American Society for Mass Spectrometry (2020)
In the past, we developed a method inferring physicochemical properties from ion mobility mass spectrometry (IM-MS) data from polydisperse synthetic homopolymers. We extend here the method to biomolecules that are generally monodisperse. Similarities in the IM-MS behavior were illustrated on proteins and peptides. This allows one to identify ionic species for which intramolecular interactions lead to specific structures.