Anti-Apoptosis and Autophagy Effects of Melatonin Protect Rat Chondrocytes against Oxidative Stress via Regulation of AMPK/Foxo3 Pathways.

Zhaoxun ChenChen ZhaoPengcheng LiuHaohan HuangShuhong ZhangXiaoqing Wang

Published in: Cartilage (2021)

Our results indicated that melatonin protected chondrocytes via mitochondrial redox homeostasis and autophagy. The effects of melatonin on senescence may apply to other age-related diseases. Thus, melatonin may have multiple potential therapeutic applications.

Keyphrases

oxidative stress
dna damage
endoplasmic reticulum stress
cell death
signaling pathway
diabetic rats
ischemia reperfusion injury
induced apoptosis
extracellular matrix
endothelial cells
cell proliferation
heat shock