Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats.
Jungbin SongYoung-Sik KimDong-Hun LeeHocheol KimPublished in: BMC complementary medicine and therapies (2020)
The oral approximate lethal dose (the lowest dose that causes mortality) of HT047 was greater than 5000 mg/kg in male and female rats. The oral no-observed-adverse-effect level of HT047 was greater than 5000 mg/kg/day in rats of both sexes, and no target organs were identified. The present findings support the safety of an herbal extract of P. lobata and S. baicalensis as a therapeutic agent for stroke and further confirm the safety of the combined use of P. lobata and S. baicalensis in clinical practice.