Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis.

Kaarina KowalecArvid HarderCasandra DolovichKathryn C Fitzgerald Salter AmberYi LuCharles N BernsteinJames M BoltonGary CutterJohn D FiskJoel GelernterLesley A GraffSara HäggCarol A HitchonDaniel F LeveyFred D LublinKyla A McKayScott PattenAmit PatkiMurray B SteinHemant K TiwariJerry S WolinskyRuth A Marrie

Published in: Annals of clinical and translational neurology (2024)

Higher genetic burden for anxiety was associated with significantly increased odds of moderate anxious symptoms in MS of European genetic ancestry which did not differ from those with anxiety and no comorbid immune disease. This study suggests a genetic basis for anxiety in MS.

Keyphrases

multiple sclerosis
sleep quality
mass spectrometry
genome wide
ms ms
copy number
depressive symptoms
dna methylation
white matter
risk factors