Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis.
Josiane Fernandes da SilvaJuliano V AlvesJulio A Silva-NetoRafael M CostaKarla Bianca NevesRheure Alves-LopesLivia L CarmargoFrancisco J RiosAugusto C MontezanoRhian M TouyzRita de Cássia TostesPublished in: Clinical science (London, England : 1979) (2021)
These results suggest that NOX5, by mechanisms linked to increased intracellular calcium, is key to early LPC-induced endothelial oxidative stress and pro-inflammatory processes. Since these are essential events in the formation and progression of atherosclerotic lesions, the present study highlights an important role for NOX5 in atherosclerosis.