Oligosaccharides from black ginseng innovatively prepared by low temperature steam-heating process ameliorate cognitive impairment in Alzheimer's disease mice via the Keap-1/Nrf2 pathway.
Weiyin XuPeng YuSimeng ShaoZhaoyang XieYi WuJianing LiuTianyang XuGuangzhi CaiHongmei YangPublished in: Journal of the science of food and agriculture (2024)
Our results showed for the first time a clear role for OSBG in improving scopolamine-induced memory impairment by inhibiting cholinergic dysfunction in a tissue-dependent manner. Additionally, OSBG administration relieved oxidative stress by activating the Keap-1/Nrf2 pathway and modulating the gut microbiota. Collectively, OSBG may be a promising target for neuroprotective antioxidants for improving memory and cognition in AD patients. This article is protected by copyright. All rights reserved.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- end stage renal disease
- cognitive impairment
- chronic kidney disease
- working memory
- newly diagnosed
- dna damage
- peritoneal dialysis
- ischemia reperfusion injury
- prognostic factors
- induced apoptosis
- protein protein
- type diabetes
- high glucose
- small molecule
- drug induced
- heat shock protein
- insulin resistance
- heat shock