Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Pan MaJing LiuJuan QinLulu LaiGyu Seong HeoHannah LuehmannDeborah SultanAndrea BredemeyerGeetika BajapaGuoshuai FengJesus JimenezRuijun HeAntanisha ParksJunedh M AmruteAna VillanuevaYongjian LiuChieh-Yu LinMatthias MackAlexander G BickJavid J MoslehiKory J LavinePublished in: Circulation (2023)
These data demonstrate that ICI myocarditis is associated with the expansion of a specific population of IFN-γ-induced inflammatory macrophages and suggest the possibility that IFN-γ blockade may be considered as a treatment option for this devastating condition.