Tocotrienols Influence Body Weight Gain and Brain Protein Expression in Long-Term High-Fat Diet-Treated Mice.
Yugo KatoYoshinori AokiKoji FukuiPublished in: International journal of molecular sciences (2020)
Obesity induces serious diseases such as diabetes and cardiovascular disease. It has been reported that obesity increases the risk of cognitive dysfunction. Cognitive dysfunction is a characteristic symptom of Alzheimer's and Parkinson's diseases. However, the detailed mechanisms of obesity-induced cognitive dysfunction have not yet been elucidated. The onset and progression of obesity-induced severe secondary diseases such as diabetes, cardiovascular events, and hypertension are deeply connected to oxidative stress. We hypothesized that obesity induces cognitive dysfunction via acceleration of reactive oxygen species (ROS) production. Vitamin E, which is a lipophilic vitamin, has strong antioxidative effects and consists of two groups: tocopherols and tocotrienols. Recently, it has been demonstrated that tocotrienols have strong neuroprotective and anti-obesity effects. In this study, we fed mice a high-fat diet (HFD) from 9 to 14 months of age and assessed the effect of tocotrienols treatment on body weight, brain oxidation levels, and cognitive function. The results revealed that treatment with tocotrienols inhibited body weight gain; further, tocotrienols reached the brain and attenuated oxidation in HFD-treated mice. These results indicate that tocotrienols have anti-obesity effects and inhibit obesity-induced brain oxidation.
Keyphrases
- weight gain
- insulin resistance
- high fat diet
- high fat diet induced
- type diabetes
- weight loss
- metabolic syndrome
- cardiovascular disease
- body mass index
- birth weight
- adipose tissue
- oxidative stress
- cardiovascular events
- reactive oxygen species
- skeletal muscle
- diabetic rats
- resting state
- white matter
- blood pressure
- high glucose
- functional connectivity
- glycemic control
- nitric oxide
- hydrogen peroxide
- brain injury
- dna damage
- coronary artery disease
- cerebral ischemia
- drug induced
- endothelial cells
- combination therapy
- electron transfer
- subarachnoid hemorrhage
- blood brain barrier
- visible light
- preterm birth