Population pharmacokinetics of olanzapine in children.
Anil R MaharajHuali WuKanecia O ZimmermanJulie AutmizguineRohit KalraAmira Al-UzriCatherine M T SherwinStuart L GoldsteinKevin M WattJinson ErinjeriElizabeth H PayneMichael Cohen-WolkowiezChristoph P HornikPublished in: British journal of clinical pharmacology (2020)
We developed a paediatric PopPK model for enterally-administered olanzapine. To our knowledge, this analysis is the first study to characterize the PK of olanzapine in participants ranging from infants to adolescents. Body weight and PMA were identified as influential covariates for characterizing developmental changes in olanzapine apparent clearance.