This paper presents an implantable impulse-radio ultra-wideband (IR-UWB) wireless telemetry system for intracortical neural sensing interfaces. A 3-dimensional (3-D) hybrid impulse modulation that comprises phase shift keying (PSK), pulse position modulation (PPM) and pulse amplitude modulation (PAM) is proposed to increase modulation order without significantly increasing the demodulation requirement, thus leading to a high data rate of 1.66 Gbps and an increased air-transmission range. Operating in 6 - 9 GHz UWB band, the presented transmitter (TX) supports the proposed hybrid modulation with a high energy efficiency of 5.8 pJ/bit and modulation quality (EVM< -21 dB). A low-noise injection-locked ring oscillator supports 8-PSK with a phase error of 2.6°. A calibration free delay generator realizes a 4-PPM with only 115 μW and avoids potential cross-modulation between PPM and PSK. A switch-cap power amplifier with an asynchronous pulse-shaping performs 4-PAM with high energy efficiency and linearity. The TX is implemented in 28 nm CMOS technology, occupying 0.155mm 2 core area. The wireless module including a printed monopole antenna has a module area of only 1.05 cm 2 . The transmitter consumes in total 9.7 mW when transmitting -41.3 dBm/MHz output power. The wireless telemetry module has been validated ex-vivo with a 15-mm multi-layer porcine tissue, and achieves a communication (air) distance up to 15 cm, leading to at least 16× improvement in distance-moralized energy efficiency of 45 pJ/bit/meter compared to state-of-the-art.