Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice.

Geng LuoMeiqi HouBo WangZhenxing LiuWenqiang LiuTiantian HanDazhi ZhangXiaopei ZhouWeimin JiaYang TanYanling WuJiarui WangXianqin Zhang

Published in: Andrology (2020)

We demonstrate that deficiency of Tsga10 gene can lead to male infertility in mice. TSGA10 is involved in the correct arrangement of mitochondrial sheath in spermatozoa. Future studies on TSGA10 include an in-depth exploration of the underlying mechanisms of TSGA10 in spermatogenesis, early embryonic development and GnRH network.

Keyphrases

oxidative stress
high fat diet induced
type diabetes
current status
optical coherence tomography
gene expression
adipose tissue
skeletal muscle
wild type
case control
smoking cessation