Serious infections in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA): a time-trend national US study.

Incidence of serious infections, especially sepsis, increased in both PMR and GCA cohorts over time. Interventions to improve serious infection outcomes in PMR/GCA are needed. Key Points • PMR/GCA patients with hospitalized serious infections were 2 decades older than the general population. • Sepsis surpassed pneumonia as the commonest hospitalized serious infection in PMR/GCA in 2011-2012. • Sepsis, female sex, comorbidity, Medicare/Medicaid insurance, and urban location were associated with higher healthcare utilization and in-hospital mortality.