Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma.

Michele IulianiSonia SimonettiFrancesco PantanoGiulia RibelliAlberto Di MartinoVincenzo DenaroBruno VincenziAntonio RussoGiuseppe ToniniDaniele Santini

Published in: Biology (2021)

Overall, the "direct" effect of cabozantinib on OBs "indirectly" increased its antitumor activity in metastatic RCC Caki-1 cells but not in the primary 786-O model.

Keyphrases

renal cell carcinoma
squamous cell carcinoma
small cell lung cancer
induced apoptosis
cell cycle arrest
metastatic renal cell carcinoma
bone mineral density
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation
body composition
oxidative stress