Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid.

Muhammad Fakhar-E-Alam KulyarQuan MoWangyuan YaoYan LiShah NawazKyein San LoonAhmed Ezzat AhmedAiman A AlsaeghKhalid M Al SyaadMuhammad AkhtarZeeshan Ahmad BhuttaJiakui LiDesheng Qi

Published in: Cell communication and signaling : CCS (2024)

Targeting Bcl-2-mediated regulation might be a possible treatment for chondrocyte-related conditions. Moreover, these results add knowledge of the complicated processes underlying chondrocyte function and the pathophysiology of related diseases, highlighting the significance of target specific therapies. Video Abstract.

Keyphrases

healthcare
oxidative stress
transcription factor
cell death
endoplasmic reticulum stress
cancer therapy
cell cycle arrest
extracellular matrix
signaling pathway
combination therapy
replacement therapy