Large-Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis.

Chiara BellocchiJun YingEllen A GoldmuntzLynette Keyes-ElsteinJohn VargaMonique E HinchcliffMarka A LyonsPeter McSweeneyDaniel E FurstRichard NashLeslie J CroffordBeverly WelchJonathan G GoldinAshley PinckneyMaureen D MayesKeith M Sullivan Shervin Assassi

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Diffuse cutaneous SSc has a distinct serum protein profile with prominent dysregulation of proteins related to fibrosis and immune cell adhesion/diapedesis. The differential expression for most serum proteins in SSc is likely to originate outside the peripheral blood cells.

Keyphrases

peripheral blood
systemic sclerosis
cell adhesion
interstitial lung disease
single cell
induced apoptosis
gene expression
cell cycle arrest
stem cells
binding protein
mesenchymal stem cells
wound healing
drug induced