Antibody-mediated procoagulant platelet formation in COVID-19 is AKT dependent.

Lisann PelzlAnurag SinghJonas FunkAndreas WitzemannIrene MariniJan ZlamalKaroline WeichWissam Abou-KhalelStefanie HammerGuenalp UzunKarina AlthausTamam Bakchoul

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Our study shows that pAKT/AKT signaling pathway is associated with the formation of procoagulant platelets in severe COVID-19 patients without integrin GPIIb/IIIa engagement. The inhibition of PI3K/AKT phosphorylation might represent a promising strategy to reduce the risk for thrombosis in patients with severe COVID-19.

Keyphrases

signaling pathway
pi k akt
sars cov
coronavirus disease
cell proliferation
cell cycle arrest
induced apoptosis
epithelial mesenchymal transition
early onset
respiratory syndrome coronavirus
pulmonary embolism
social media
oxidative stress
endoplasmic reticulum stress