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Antibody-mediated procoagulant platelet formation in COVID-19 is AKT dependent.

Lisann PelzlAnurag SinghJonas FunkAndreas WitzemannIrene MariniJan ZlamalKaroline WeichWissam Abou-KhalelStefanie HammerGuenalp UzunKarina AlthausTamam Bakchoul
Published in: Journal of thrombosis and haemostasis : JTH (2021)
Our study shows that pAKT/AKT signaling pathway is associated with the formation of procoagulant platelets in severe COVID-19 patients without integrin GPIIb/IIIa engagement. The inhibition of PI3K/AKT phosphorylation might represent a promising strategy to reduce the risk for thrombosis in patients with severe COVID-19.
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