Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.

Maria B PaduaPoornima Bhat-NakshatriManjushree AnjanappaMayuri S PrasadYangyang HaoXi RaoSheng LiuJun WanYunlong LiuKyle McElyeaMax JacobsenGeorge SanduskySandra AlthouseSusan PerkinsHarikrishna Nakshatri

Published in: Breast cancer research : BCR (2018)

These studies reveal an unexpected role of the axon guidance receptor UNC5A in fine-tuning ERα and EGFR signaling and the luminal progenitor status of hormone-sensitive breast cancers. Furthermore, UNC5A knockdown cells provide an ideal model system to investigate metastasis of ERα+ breast cancers.

Keyphrases

induced apoptosis
small cell lung cancer
estrogen receptor
breast cancer cells
epidermal growth factor receptor
air pollution
tyrosine kinase
genome wide
single cell
binding protein
gene expression
oxidative stress
signaling pathway
young adults
dna methylation
endoplasmic reticulum stress