Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia.
Franca RaucciClaudio VernieriMaira Di TanoFrancesca LigorioOlga BlaževitšSamuel LazzeriAnastasiya ShmahalaGiuseppe FragaleGiulia SalvadoriGabriele VaranoStefano CasolaRoberta BuonoEuplio ViscoFilippo G De BraudValter Daniel LongoPublished in: Cancer research (2024)
Chronic lymphocytic leukemia cells resist fasting-mimicking diet by inducing proteasome activation to escape starvation, which can be targeted using proteasome inhibition by bortezomib treatment to impede leukemia progression and prolong survival.
Keyphrases
- chronic lymphocytic leukemia
- physical activity
- multiple myeloma
- weight loss
- insulin resistance
- induced apoptosis
- blood glucose
- acute myeloid leukemia
- type diabetes
- bone marrow
- cell cycle arrest
- newly diagnosed
- cancer therapy
- skeletal muscle
- cell death
- adipose tissue
- combination therapy
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- free survival