Osteogenic activities of four calcium-chelating microalgae peptides.

Published in: Journal of the science of food and agriculture (2022)

Microalgae proteins have favorable digestibilities. Among the four MPHs, Nannochloropsis oceanica protein hydrolysates showed the highest calcium-chelating capacity, which might be due to its high degree of hydrolysis after in vitro digestion and high content of Ser, Tyr, Thr, Asp and Glu. The absorption intensities and particle sizes of MPHs both increased after calcium addition. MPH treatment could reverse dexamethasone-induced osteoporosis of zebrafish, and MPHs-Ca chelates showed higher osteogenic activities in osteoporosis-like phenotype zebrafish. © 2022 Society of Chemical Industry.

Keyphrases

anaerobic digestion
mesenchymal stem cells
postmenopausal women
bone marrow
bone mineral density
amino acid
high glucose
low dose
diabetic rats
oxidative stress
body composition
small molecule
endothelial cells
protein kinase